A WARNING FOR WELL-TO-DO, WELL-NOURISHED MEN: DON’T DISMISS REFLUX
Thursday, March 12th, 2009No one can explain it, but in the past decade well-to-do middle-aged men have begun falling victim to a previously rare form of cancer. This has happened particularly to white men. There has been no change in the incidence of this cancer among Asian and black men or among women.
It’s a cancer thought to be directly related to reflux – the surging up of stomach acid into the food pipe. The tragedy of this adenocarcinoma of the oesophagus or gullet is that it is lethal. Only 10 per cent of sufferers survive for more than 5 years.
Mysteriously, the incidence among white men living in Western societies is increasing at a rate of 10 per cent a year. In the past, a different kind of gullet cancer was predominant. About 20 years ago people tended to get squamous-cell carcinoma of the oesophagus, which was strongly related to smoking and the ingestion of alcohol. Now, as squamous-cell carcinoma levels have plateaued and even fallen off in men, the incidence of adenocarcinoma in men has begun increasing at a frightening pace. It is now occurring in three Australian men in every 100 000, and is particularly prevalent among the well-nourished and well-to-do.
The gullet is lined with a kind of skin, so it is understandable that squamous-cell carcinoma, which is a skin-like cancer, can grow there. It is more difficult to understand how adenocarcinoma, which is a gland-like cancer, can develop there.
Adenocarcinoma has a glandular cell structure and usually grows in glands such as those in the stomach, the pancreas and the bowel. It is abnormal to find it in the gullet. A healthy man would have no glandular tissue in his oesophagus.
It is thought that long-standing severe reflux starts the process that ultimately leads to this cancer. Of course, most men with reflux never develop it, but all those who do have it have a history of reflux.
Reflux occurs when the contents of the stomach get washed back up the gullet because the valve between the gullet and the stomach is not efficient enough to keep the acid and food in the stomach. It is thought that over the years the acid burns the skin lining off the lower end of the gullet and is gradually replaced by a different kind of lining, which is more resistant to acid.
This new lining is made up of gastric-type cells, which behave as if they were in the stomach. It looks like the gastric cells have broken out of the stomach and begun growing up the gullet. When this happens, a man is said to have a condition known as Barrett’s oesophagus. There are thousands of men out there with reflux, and it is not known why some develop a Barrett’s lining and others don’t.
Barrett’s is a precursor to this cancer, and it is not understood why some people with Barrett’s develop the cancer and others do not. When adenocarcinoma grows in the Barrett’s lining, it looks and acts like gastric cancer.
It is thought that a Barrett’s lining takes decades to develop.
When, for example, it is found in a 50-year-old man, there is characteristically at least a 20-year history of reflux.
One difficulty with Barrett’s is that men are unaware of it. It does not show up with a barium meal and X-ray and can only be found through an endoscopic examination. Because the lining has changed, it copes much better when acid is washed past, and the man may feel less pain or discomfort. With a Barrett’s oesophagus, reflux may effectively become a silent condition.
If, after a long time, a man notices a change in his reflux pattern, it could be a sign of Barrett’s. If he has had persistent reflux for 20 years and then, in the absence of new medication or a changed diet, his reflux seems to fade, he should be checked for the condition.
Tests show that men with Barrett’s have more acid in their gullet but that it does not seem to hurt as much. They also show that the valve between their gullet and stomach operates at a much lower pressure, which makes it less efficient. Usually, these men also have a hiatus hernia, which occurs when a portion of the stomach protrudes upwards through the diaphragm. This is a major factor in the valve losing pressure. Men commonly develop this hernia as they age.
At any one time, about one-third of the male population will have abnormal reflux. About 10 per cent of this third will develop Barrett’s. Of them, 10 per cent may develop adenocarcinoma of the oesophagus.
In New South Wales, about 250 people die from this cancer every year, and the vast majority of them are men. Some specialists say an effective preventive measure against Barrett’s and reflux is a hiatus hernia repair. The theory is that the hernia leads to valve weakening, which leads to reflux, which leads to Barrett’s, which leads to the cancer.
With keyhole surgery, the hernia can be repaired in an operation requiring just 2 days in hospital. Surgery for adenocarcinoma of the oesophagus is more drastic than open-heart surgery and involves removing part of the lower oesophagus and part of the upper stomach, then using the remaining stomach to form a tube to reconstitute the plumbing. During this operation, appropriate lymph nodes are also removed. Surgery certainly appears to improve men’s chances of surviving for a number of years.
Affluent men should be alert to a change in their digestion patterns. If food starts to stick or the man has difficulty swallowing or needs to drink water to get food down, he should see his doctor.
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